3 years ago

Effects of Moxonidine and Low-Calorie Diet: Cardiometabolic Benefits from Combination of Both Therapies

Geoffrey A. Head, Nora E. Straznicky, Gavin W. Lambert, Murray Esler, John B. Dixon, Sarah E. Phillips, Elisabeth A. Lambert, Carolina I. Sari, Mariee Grima, Nina Eikelis, Markus P. Schlaich
Objective Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of a centrally acting sympatholytic agent, the effects of a weight loss (WL) program using a low-calorie diet, and the effects of a combination of both. Methods Young (18-30 years) male subjects with overweight (BMI > 25 kg/m2) were allocated to a WL program (n = 10), a moxonidine treatment course (M; n = 10, 0.4 mg/d), a combination of both (WL + M; n = 11), or to a control (C) group (n = 6) for 6 months. Muscle sympathetic nerve activity (MSNA), endothelial function, renal function (Cockcroft-Gault formula), and the metabolic profile were assessed before and after intervention. Results WL occurred in the WL and WL + M groups (−7.6 ± 1.9 kg, P < 0.001 in both). MSNA and systolic blood pressure decreased similarly in the WL, M, and WL + M groups (by ∼10 bursts/min, P < 0.001, and by ∼9 mm Hg, P < 0.05). All other parameters for the WL, C, and M groups remained unchanged. In the WL + M group, decreased total cholesterol (−0.78 ± 0.23 mmol/L, P < 0.001), decreased low-density lipoprotein cholesterol (−0.49 ± 0.16 mmol/L, P < 0.01), decreased insulin (−6.5 ± 2.8 mmol/L, P < 0.05), and attenuated glomerular hyperfiltration (−19 ± 5 mL/min, P < 0.01) occurred. Conclusions The combination of moxonidine with a WL program has beneficial effects on aspects of the metabolic profile and end organ damage in young males with overweight.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/oby.21962

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