Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Eosinophilia secondary to lenalidomide therapy

Eosinophilia secondary to lenalidomide therapy
S. Osorio-Prendes, V. Escudero-Vilaplana, E. González-Arias, M. Sanjurjo-Sáez, R. Collado-Borrell
What is known and objective Limited data are available on eosinophilia as a drug adverse event. We describe a case of eosinophilia from lenalidomide therapy. Case description A 50-year-old woman received lenalidomide, dexamethasone and cyclophosphamide as POEMS syndrome treatment. Eosinophil count rose during lenalidomide treatment and decreased in the periods off treatment. Naranjo nomogram suggested a probable association between the use of lenalidomide and eosinophilia. What is new and conclusion Eosinophilia has rarely been described with lenalidomide. This case shows a clear temporal relationship between lenalidomide and eosinophilia. We describe a patient, treated with lenalidomide for POEMS syndrome, who developed eosinophilia secondary to lenalidomide. This observation could increase the knowledge about lenalidomide safety, because, although our patient developed an isolated eosinophilia, it could be associated with life-threatening DRESS. Thus, lenalidomide should be considered as a potential cause of isolated eosinophilia, and if symptoms of DRESS appear, its discontinuation should be strongly considered. This adverse event is extremely uncommon and it is not described in lenalidomide summary of product characteristics.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12611

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