Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Severe neurological disorders and refractory aspergillosis in an adolescent treated by vincristine and voriconazole

Severe neurological disorders and refractory aspergillosis in an adolescent treated by vincristine and voriconazole
K. Masmoudi, A.-S. Lemaire-Hurtel, T. Chouaki, S. Quaranta, S. Bodeau, A. Lutun, N. Guillaume, C. Solas, A. Gourmel, Y. Bennis
What is known and objective Voriconazole and vincristine are major therapeutics in paediatric haematology. However, the risk-benefit ratio of the treatment of invasive aspergillosis with voriconazole in patients receiving vincristine-based chemotherapy remains unclear. Case description We report severe peripheral and central neurological disorders in a 14-year-old girl with T-cell acute lymphoblastic leukaemia and pulmonary aspergillosis. The case describes a strong exacerbation by voriconazole of the vincristine-induced neuropathic pains. It shows the high variability of the trough serum concentration of voriconazole leading to antifungal treatment failure and suggests that its own central neurotoxicity could also be potentiated by vincristine. What is new and conclusion Given the risk of either insufficient antifungal efficacy or excessive neurological disorders, this case warns on a probable unfavourable risk-benefit profile of voriconazole during vincristine-based chemotherapy in adolescents. Voriconazole (VRC) therapeutic drug monitoring and neurological adverse events during vincristine (VCN)-based chemotherapy. We describe severe neurologic disorders due to interactions between vincristine and voriconazole in a 14-year-old girl. We also report a high fluctuation of the voriconazole serum concentration and treatment failure of the aspergillosis despite close therapeutic drug monitoring. This case warns on a risk-benefit ratio of voriconazole probably unfavorable when associated to vincristine-based chemotherapy in pediatric hematology.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12603

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