Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Ciprofloxacin-induced immune-mediated thrombocytopenia: No cross-reactivity with gemifloxacin

Ciprofloxacin-induced immune-mediated thrombocytopenia: No cross-reactivity with gemifloxacin
J. Jeong, D. W. Sim, Y.-I. Koh, J. E. Yu
What is known and objective Fluoroquinolone-induced immune-mediated thrombocytopenia is uncommon, and no reports of cross-reactivity among fluoroquinolones exist. Here, we describe a case of ciprofloxacin-induced immune thrombocytopenia with no cross-reactivity with gemifloxacin. Case description A 77-year-old woman showed profound thrombocytopenia immediately after two ciprofloxacin injections for pneumonia. Platelet counts recovered rapidly after ciprofloxacin discontinuation. She had experienced thrombocytopenia after ciprofloxacin administration 4 years earlier, which was assumed to be ciprofloxacin-induced immune-related. Interestingly, no thrombocytopenia occurred following the subsequent exposure to another fluoroquinolone, gemifloxacin. What is new and conclusion No cross-reactivity occurred between ciprofloxacin and gemifloxacin in this fluoroquinolone-induced immune thrombocytopenia case. Changes in blood platelet count following administration of various antibiotics during admission.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12596

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