Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Spontaneous pregnancy during ulipristal acetate treatment of giant uterine leiomyoma

Spontaneous pregnancy during ulipristal acetate treatment of giant uterine leiomyoma
D. Habek, S. Jerkovic Gulin, J. Cerkez Habek, D. Gulin, I. Hrgovic, Z. Hrgovic
What is known and objective Ulipristal acetate, a progesterone receptor modulator, pharmacologically inhibits endometrial proliferation and thereby prevents pregnancy. It is primarily used as emergency contraception, but also for the treatment of fibroids in women of reproductive age. There have been no published cases of pregnancy, while on therapy with ulipristal acetate. Case description In this article, we present a case report of spontaneous pregnancy during ulipristal acetate therapy. What is new and conclusion To our knowledge, this is the first patient with spontaneous conception, while on ulipristal acetate treatment. There were no drug-related complications, and the pregnancy resulted in the delivery of a healthy baby. Ulipristil acetate (UA), inhibits endometrial proliferation and prevents pregnancy, a case of spontaneous pregnancy during UA therapy for fibroids and delivery of a healthy baby.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12590

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