Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
4 years ago

Pericarditis during infliximab therapy in paediatric ulcerative colitis

Pericarditis during infliximab therapy in paediatric ulcerative colitis
V. Dipasquale, M. A. Catena, C. Romano, S. M. C. Gramaglia
What is known and study objective Infliximab is a widely used drug for treating inflammatory bowel disease (IBD). This drug is known to rarely cause pericarditis in adult populations. Case summary This report details the case of a 14-year-old boy with ulcerative colitis who developed pericarditis after a second infliximab infusion. After discontinuation of therapy, the patient's symptoms were resolved. What is new and conclusion To our knowledge, this is the first reported paediatric case of pericarditis as a possible complication of infliximab therapy in IBD. Among infliximab-related delayed adverse reactions, cardiac complications should be monitored in the paediatric population. Infliximab, a widely used drug for treating inflammatory bowel disease (IBD), is known to rarely cause pericarditis in adult populations. In this report, we communicate a case of pericarditis after a second infliximab infusion in a 14-year-old boy with ulcerative colitis. To our knowledge, this is the first reported paediatric case of pericarditis as a possible complication of infliximab therapy in IBD.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12586

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