Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Efficacy of sofosbuvir and ledipasvir in an HCV+ gastro-resected patient

Efficacy of sofosbuvir and ledipasvir in an HCV+ gastro-resected patient
A. De Nicolò, A. D'Avolio, A. R. Garbuglia, M. Tempestilli, M. Montalbano, G. D'Offizi, C. Taibi
What is known and objective The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. Case description We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs. She obtained sustained virological response at week 12 and 24 without dose adjustment. What is new and conclusion This case report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating actual SOF/LDV bioavailability. We describe the first reported case of treatment with direct antiviral agents in a gastrotomized patient. This report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating Sofosbuvir/Ledipasvir bioavailability.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12546

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