Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
5 years ago

Lercanidipine-induced chylous ascites: Case report and literature review

Lercanidipine-induced chylous ascites: Case report and literature review
A. Huerta, I. A. Rosado, J. E. Basualdo, J. F. Lucena, F. Alegre, M. I. Morales, M. F. Landecho, N. Fernández-Ros
What is known and objective Chylous ascites is a rare condition. The most frequent causes are lymphomas, solid malignancies, abdominal trauma and cirrhosis. Isolated case reports describe the relationship between calcium channel blockers (CCB) and chyloperitoneum. Lercanidipine is a third-generation dihydropyridine with low rate of adverse events. We describe a case of lercanidipine-induced chylous ascites. Case summary An 80-year-old white female with hypertension treated with lercanidipine, developed chylous ascites and abdominal pain after the dosage of the CCB was doubled. The initial suspicion was a hidden neoplasm, but after a thorough research, no apparent cause was detected and the symptoms resolved after the drug was suspended. What is new and conclusion Calcium channel blockers should be considered as possible causes in cases of chyloperitoneum of unknown aetiology. Chylous ascites induced by lercanidipine in a patient with constitutional symptoms without evidence of hidden malignancy by PET/CT.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12555

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