3 years ago

Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides
Watchara Srimontree, Hsuan-Hung Liao, Magnus Rueping, Adisak Chatupheeraphat
A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)–C(sp) bond formation in a straightforward and mild fashion.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01194

DOI: 10.1021/acs.orglett.7b01194

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