American Journal of Transplantation
American Journal of Transplantation
5 years ago

American Journal of Transplantation: Volume 17, Number 9, September 2017

On the cover this month: Epigenetic regulation is mediated by changes to a gene, such as DNA methylation and histone modification, that do not change the genetic sequence, but nevertheless alter the expression or function of the gene. A common family of molecules involved in epigenetic gene alteration are the bromo and extra-terminal (BET) proteins. Notable among these are the bromodomain (BRD) proteins, which influence numerous pathways known to be involved in alloimmunity. This month, Suarez-Alvarez et al (page 2254) present a minireview on BET proteins, highlighting their role in immunity and potential as targets for antirejection therapies. Also, two papers (Mathews et al, page 2285 and Cortes- Cerisuelo et al, page 2350) provide new information relevant to the etiology of belatacept-resistant rejection. Cover image by Lauren Halligan, Duke University Department of Surgery.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14423

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