3 years ago

American Journal of Transplantation: Volume 17, Number 9, September 2017

On the cover this month: Epigenetic regulation is mediated by changes to a gene, such as DNA methylation and histone modification, that do not change the genetic sequence, but nevertheless alter the expression or function of the gene. A common family of molecules involved in epigenetic gene alteration are the bromo and extra-terminal (BET) proteins. Notable among these are the bromodomain (BRD) proteins, which influence numerous pathways known to be involved in alloimmunity. This month, Suarez-Alvarez et al (page 2254) present a minireview on BET proteins, highlighting their role in immunity and potential as targets for antirejection therapies. Also, two papers (Mathews et al, page 2285 and Cortes- Cerisuelo et al, page 2350) provide new information relevant to the etiology of belatacept-resistant rejection. Cover image by Lauren Halligan, Duke University Department of Surgery.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14423

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.