Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Supercharging Proteins: How Many Charges Can a Protein Carry?

Supercharging Proteins: How Many Charges Can a Protein Carry?
Nicolas C. Polfer
Very highly charged proteins, so-called “supercharged” ions, can lose (excess) protons to background gases like N2. It is remarkable that such extremely acidic species can be generated in electrospray ionization, in the presence of not just N2 but also much higher-basicity solvents. What mechanism(s) can explain such high charging, and what is the ultimate limit?

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704527

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