BJU International
BJU International
5 years ago

Association between Metabolic Syndrome and intravesical prostatic protrusion in benign prostatic enlargement patients with lower urinary tract symptoms (MIPS Study)

G. Morgia, M. Carini, F. Regis, M. Gacci, J. Frizzi, P. Spatafora, G I Russo, S. Serni, D. Urzì, S. Cimino
Objective To investigate the association between metabolic syndrome (MetS) and morphological features of benign prostatic enlargement (BPE), including total prostate volume (TPV), transitional zone volume (TZV) and intra vesical prostatic protrusion (IPP). Patients and Methods From January 2015 to January 2017, 224 consecutive men older than 50 years presenting with lower urinary tract symptoms (LUTS) suggestive of BPE were recruited in this multicentre cross-sectional study. MetS was defined according to international diabetes federation criteria. Multivariate linear and logistic regression models were performed to verify factors associated with IPP, TZV and TPV. Results Patients with MetS showed significantly increase of IPP (p<0.01), TPV (p<0.01) and TZV (p=0.02). At the age-adjusted linear regression analysis, adjusted for age and metabolic factors of MetS, we found that HDL was negatively associated with IPP (r= -0.17), TPV (r= -0.19) and TZV (r= -0.17), while hypertension was positively associated with IPP (r= 0.16), TPV (r= 0.19) and TZV (r= 0.16). At the multivariate logistic regression analysis adjusted for age and factors of MetS, hypertension (categorical) (OR= 2.95), HDL (OR= 0.94) and triglycerides (OR= 1.01) were independent predictors of TPV ≥ 40 cc. We also found that HDL (OR: 0.86), hypertension (OR =2.0) and WC (OR: 1.09) were significantly associated with TZV ≥ 20 cc. At the age-adjusted logistic regression analysis, MetS was significantly associated with IPP ≥ 10 mm (OR= 34.0; p<0.01), TZV ≥ 20 cc (OR= 4.40; p<0.01) and TPV ≥ 40 cc (OR= 5.89; p=0.03). Conclusion MetS shows association with BPE demonstrating relationship with IPP. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bju.14007

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.