Organic Letters
Organic Letters
5 years ago

Nicotabin A, a Sesquiterpenoid Derivative from Nicotiana tabacum

Nicotabin A, a Sesquiterpenoid Derivative from Nicotiana tabacum
Zheng-Hui Li, Tao Feng, Ji-Kai Liu, Jun He, Hong-Lian Ai, He-Ping Chen, Xiao-Nian Li, Xue-Mei Li
Nicotabin A (1), a sesquiterpenoid derivative possessing a fused 5/6/5/5/5 ring system, was isolated from leaves of Nicotiana tabacum. The structure was elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. The plausible biosynthetic pathway for 1 was proposed. Compound 1 inhibited nitric oxide production in LPS-activated RAW264.7 macrophages with an IC50 of 22.1 μM.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02559

DOI: 10.1021/acs.orglett.7b02559

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