Organic Letters
Organic Letters
5 years ago

Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes

Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes
Xu Zhang, Xuefeng Xu
A unique and direct approach for constructing 4-quinolones from simple and readily available anilines and alkynes is described. Under the optimal conditions, both N-alkyl- and N-aryl-substituted anilines can be successfully transformed into the corresponding 4-quinolones. This reaction is characterized by mild reaction conditions, high functional-group tolerance, and amenability to gram-scale synthesis.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02495

DOI: 10.1021/acs.orglett.7b02495

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