Organic Letters
Organic Letters
5 years ago

Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides

Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides
Zhihong Li, Biao Jiang, Hongli Chen, Jiakang Chen, Rong Huang, Yuexiong Zhan, Hongtao Xu, Xianhao Zhou
A new class of N-phenyl-divinylsulfonamides which can be easily prepared have been successfully developed and utilized as efficient linkers in the field of disulfide bond modification. Functional divinylsulfonamides provide opportunities for the specific introduction of various functionalities, including affinity probes, fluorescent tags, and drugs, into peptides.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02464

DOI: 10.1021/acs.orglett.7b02464

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