5 years ago

Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation

Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation
Norbert Sewald, Christian Schnepel
C−H functionalization belongs to the most challenging topics of synthetic chemistry due to the dilemma of substrate vs. catalyst control. Remarkably, halogenating enzymes provide a “green” approach for site-selective C–H functionalization that is often superior to conventional methodologies. Only molecular oxygen and halide salts are required for highly selective electrophilic halogenation under ambient conditions. Recently considerable efforts were made to enhance the preparative utility of halogenating enzymes. The application scope was expanded towards more robust biocatalysts enabling enzymatic halogenation of a wide range of arenes. Timely developments of biohalogenation regarding preparative synthesis, engineering and cascade processes are being discussed in the minireview by C. Schnepel and N. Sewald on page 12064 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785065

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.