Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation

Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation
Norbert Sewald, Christian Schnepel
C−H functionalization belongs to the most challenging topics of synthetic chemistry due to the dilemma of substrate vs. catalyst control. Remarkably, halogenating enzymes provide a “green” approach for site-selective C–H functionalization that is often superior to conventional methodologies. Only molecular oxygen and halide salts are required for highly selective electrophilic halogenation under ambient conditions. Recently considerable efforts were made to enhance the preparative utility of halogenating enzymes. The application scope was expanded towards more robust biocatalysts enabling enzymatic halogenation of a wide range of arenes. Timely developments of biohalogenation regarding preparative synthesis, engineering and cascade processes are being discussed in the minireview by C. Schnepel and N. Sewald on page 12064 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785065

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