Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Frontispiece: Catalysis of Michael Additions by Covalently Modified G-Quadruplex DNA

Frontispiece: Catalysis of Michael Additions by Covalently Modified G-Quadruplex DNA
Surjendu Dey, Andres Jäschke, Carmen L. Rühl
Guanosine-rich DNA sequences can fold into quadruplex structures which are not only biologically relevant, but also promising for applications in aqueous homogenous catalysis. Here, an asymmetric Michael addition is catalyzed by covalently modified G-quadruplexes in combination with copper ions. Using systematic chemical variation and various spectrometric techniques, the key parameters that govern rate acceleration and stereoselectivity were identified. More information can be found in the Full Paper by A. Jäschke et al. on page 12162 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785068

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