5 years ago

Frontispiece: Record Broken: A Copper Peroxide Complex with Enhanced Stability and Faster Hydroxylation Catalysis

Frontispiece: Record Broken: A Copper Peroxide Complex with Enhanced Stability and Faster Hydroxylation Catalysis
Kai Stührenberg, Roland Schoch, Ivana Ivanović-Burmazović, Maximilian Dürr, Alexander Hoffmann, Isabella Sommer, Patricia Liebhäuser, Thomas Schnappinger, Sonja Herres-Pawlis, Claudia Wilfer, Matthias Bauer, Anne Thoma, Kristina Keisers
Bis(pyrazolyl)methane copper peroxide complexes display tyrosinase-like catalytic phenol hydroxylation activity. An exchange of the pyridinyl unit (background) by a methylimidazolyl unit (middle) enhances the catalytic activity. In turn, substituting the pyridinyl with a carboxymethyl group (foreground) enhances the stability and the catalytic activity in catalytic phenol hydroxylation. This makes the presented tyrosinase model the fastest catalytic model. Kinetic measurements reveal substrate-binding behaviour and a biomimetic electrophilic reaction mechanism. DFT calculations show that the carboxymethyl substituent weakens the pyridinyl donor, which enhances the activity. For more details, see the Full Paper by S. Herres-Pawlis et al. on page 12171 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785069

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