Shuttle Catalysis—New Strategies in Organic Synthesis

5 years ago

Shuttle Catalysis—New Strategies in Organic Synthesis

Bill Morandi, Benjamin N. Bhawal

Shuttle catalysis has recently emerged as a powerful new concept that provides a platform for performing both functionalization and defunctionalization reactions. In this concept article, applications of shuttle catalysis as a novel strategy in organic synthesis are discussed. This includes using forward shuttle catalysis reactions for challenging bond-forming processes that avoid the use of hazardous chemicals. Shuttle catalysis also facilitates the transfer of reactive functionality as a route to procure a broad range of compounds using one simple procedure. Reverse shuttle catalysis reactions are also discussed as a method for the valorization of biomass and waste materials. Another area of interest, shuttle-catalysis-assisted reactions, wherein the transfer of a small molecule is utilized in a catalytic cycle, is also described. Possible future directions in this exciting new field are also suggested. Back and forth: Shuttle catalysis has recently emerged as a powerful new concept that provides a platform for performing both functionalization and defunctionalization reactions. In this Concept article, applications of shuttle catalysis as a novel strategy in organic synthesis are discussed (see figure).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201605325