3 years ago

Silver-Catalyzed Intermolecular [3 + 2]/[5 + 2] Annulation of N-Arylpropiolamides with Vinyl Acids: Facile Synthesis of Fused 2H-Benzo[b]azepin-2-ones

Silver-Catalyzed Intermolecular [3 + 2]/[5 + 2] Annulation of N-Arylpropiolamides with Vinyl Acids: Facile Synthesis of Fused 2H-Benzo[b]azepin-2-ones
Jin-Heng Li, Ming Hu, Yang Li
A silver-catalyzed oxidative intermolecular [3 + 2]/[5 + 2] annulation of N-arylpropiolamides with 4-vinyl acids for producing fused 2H-benzo[b]azepin-2-ones is described. This radical-mediated annulation reaction features broad substrate scope and excellent selectivity, and enables the formation of three new C–C bonds through oxidative decarboxylation, [3 + 2]/[5 + 2] annulations, and C(sp2)-H functionalization cascades. Employing this silver-catalyzed oxidative strategy, common terminal alkynes were successfully converted into cyclopentenes via intermolecular [3 + 2] annulation.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02061

DOI: 10.1021/acscatal.7b02061

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