5 years ago

Crowd Control: E7 Conservation Is the Key to Cancer

Crowd Control: E7 Conservation Is the Key to Cancer
Karl Munger, Elizabeth A. White

Several human papillomavirus type 16 (HPV16) oncoproteins contribute to cellular transformation in vitro. In this issue of Cell, Mirabello and colleagues use high-throughput sequencing data to assess the diversity of HPV16 isolates from human patients. These data suggest that the E7 oncoprotein is the fundamental contributor to in vivo carcinogenesis.

Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)30991-1

DOI: 10.1016/j.cell.2017.08.033

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