Converting Cold into Hot Tumors by Combining Immunotherapies
In a small phase Ib study in this issue of Cell, Ribas et al. report that the combination of intralesional injection of a modified human herpes simplex virus and systemic anti-PD-1 treatment resulted in a 62% response rate in patients with metastatic melanoma, accompanied by enhanced T cell infiltration in virus-injected lesions.
Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)30989-3
DOI: 10.1016/j.cell.2017.08.031
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