Putting Two Heads Together to Build a Better Brain
3D organoids enable in vitro human brain development models, but they have not yet recapitulated some essential features of brain circuit formation. Recently, several studies appearing in Nature, Nature Methods, and Cell Stem Cell generated fused organoid models of inhibitory and excitatory neuron development, which can now achieve functional circuit integration.
Publisher URL: http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30335-1
DOI: 10.1016/j.stem.2017.08.017
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