The TREX1 Dinosaur Bites the Brain through the LINE
![The TREX1 Dinosaur Bites the Brain through the LINE](/image/eyJ1cmkiOiJodHRwOi8vc3RhY2thZGVtaWMuaGVyb2t1YXBwLmNvbS9pbWFnZT9pbWFnZV9pZD0yMDU4MiIsImZvcm1hdCI6IndlYnAiLCJxdWFsaXR5IjoxMDAsIm5vQ2FjaGUiOnRydWV9.webp)
In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.
Publisher URL: http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30328-4
DOI: 10.1016/j.stem.2017.08.010
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