Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML
Intratumor heterogeneity driving therapeutic resistance is a major challenge in cancer management. Recently in Nature, Shlush et al. (2017) provide a tour de force of genomics coupled to functional assays to demonstrate that resistance emerges from a pre-existing subpopulation of acute myeloid leukemia (AML) cells with a stem cell transcription program.
Publisher URL: http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30322-3
DOI: 10.1016/j.stem.2017.08.004
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