3 years ago

Evaluation of osteogenic inductivity of a novel BMP2-mimicking peptide P28 and P28-containing bone composite

Hu Yang, Zengwu Shao, Yanhui Ji, Liang Yang, Yanzhen Qu, Ramphul Navinduth, Wei Cui, Wei Yu, Xiaodong Guo, Tingfang Sun
We developed a novel BMP2-mimicking peptide P28, which possess two distinct special structural elements—seven repetitive aspartic acids and phosphorylated serine designed to promote affinity to hydroxyapatite as well as nucleation of apatite crystallization and mineralization. In this work, we systematically studied the osteogenic inductivity of P28 in vivo and in vitro in comparison to BMP2. We confirmed its effects on proliferation, recruitment, and osteogenic differentiation of MC3T3-E1 cells in vitro. Furthermore, we loaded P28 into a biomimetic bone composite nano-hydroxyapatite/collagen/poly (L-lactide) (nHAC/PLA) and evaluated its ability to promote bone regeneration in vivo using a rabbit femoral condyle defect model. The micro-CT reconstruction and quantification analysis, and the histological analysis indicated that P28/nHAC/PLA bone composite was capable of repairing bone defects. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbm.a.36228

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