4 years ago

Fabrication of Calcium Phosphate Microflowers and Their Extended Application in Bone Regeneration

Fabrication of Calcium Phosphate Microflowers and Their Extended Application in Bone Regeneration
Shiyu Lin, Jinfeng Liao, Taoran Tian, Tengfei Zhou, Xiaoxiao Cai, Si-Rong Shi, Tao Zhang, Yunfeng Lin
The structure of materials is known to play an important role in material function. Nowadays, flowerlike structures have gained attention for studies not only in analytical chemistry, but also in biomaterial design. In this study, flowerlike structures were applied in bone regeneration in the form of calcium phosphate microflowers. The material was synthesized by a simple and environmentally friendly method. We characterized the structure and properties of the microflower using various methods. Cytotoxicity and osteogenesis-related gene regulations of the microflower were investigated in vitro. Cell uptake was observed by immunofluorescence. Rat calvarial critical-size defect models were successfully established to further confirm the enhanced bone regeneration ability of this material. We expect that this novel study will be of practical importance for the extended application of flowerlike materials and will provide new insights into the optimization of the morphology of calcium phosphate materials.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b09176

DOI: 10.1021/acsami.7b09176

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