3 years ago

Perylene Diimide-Grafted Polymeric Nanoparticles Chelated with Gd3+ for Photoacoustic/T1-Weighted Magnetic Resonance Imaging-Guided Photothermal Therapy

Perylene Diimide-Grafted Polymeric Nanoparticles Chelated with Gd3+ for Photoacoustic/T1-Weighted Magnetic Resonance Imaging-Guided Photothermal Therapy
Chao Yin, Yufu Tang, Wansu Zhang, Liang Chen, Feng Lu, Quli Fan, Yu Ji, Wenbo Hu, Zhen Yang, Wei Huang, Xiaomei Lu, Xiaoming Hu
Developing versatile and easily prepared nanomaterials with both imaging and therapeutic properties have received significant attention in cancer diagnostics and therapeutics. Here, we facilely fabricated Gd3+-chelated poly(isobutylene-alt-maleic anhydride) (PMA) framework pendent with perylene-3,4,9,10-tetracarboxylic diimide (PDI) derivatives and poly(ethylene glycol) (PEG) as an efficient theranostic platform for dual-modal photoacoustic imaging (PAI) and magnetic resonance imaging (MRI)-guided photothermal therapy. The obtained polymeric nanoparticles (NPs) chelated with Gd3+ (PMA–PDI–PEG–Gd NPs) exhibited a high T1 relaxivity coefficient (13.95 mM–1 s–1) even at the higher magnetic fields. After 3.5 h of tail vein injection of PMA–PDI–PEG–Gd NPs, the tumor areas showed conspicuous enhancement in both photoacoustic signal and T1-weighted MRI intensity, indicating the efficient accumulation of PMA–PDI–PEG–Gd NPs owing to the enhanced permeation and retention effect. In addition, the excellent tumor ablation therapeutic effect in vivo was demonstrated with living mice. Overall, our work illustrated a straightforward synthetic strategy for engineering multifunctional polymeric nanoparticles for dual-modal imaging to obtain more accurate information for efficient diagnosis and therapy.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b09633

DOI: 10.1021/acsami.7b09633

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