British Journal of Haematology
British Journal of Haematology
5 years ago

Chronic lymphocytic leukaemia genomics and the precision medicine era

Olivier A. Bernard, Florence Nguyen-Khac, Hussein Ghamlouch
Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients’ perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjh.14719

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