5 years ago

Highlights from this issue

The taming of the shrew

It may come as some surprise that the hedgehog is a distant relative of the shrew, and even more of a surprise that hedgehogs native to North America are now extinct and have never been present in Australia. However, hedgehog and its signalling pathways are increased in Idiopathic Pulmonary Fibrosis (IPF). In this issue of Thorax, Jia and colleagues describe how the chemokine CXCL14 is increased in mice in response to Hedgehog overexpression and is elevated in the plasma from patients with IPF (see page 780). In an effort to tame this shrew a hedgehog inhibitor has been developed and has been shown to inhibit CXCL14 in patients treated with cancer. Therefore, it is hoped CXCL14 can be used as a biomarker to demonstrate whether vismodegib can tame both the shrew and IPF.

The merry widows of windsor

Falstaff...

Publisher URL: http://thorax.bmj.com/cgi/content/short/72/9/i

DOI: 10.1136/thoraxjnl-2017-210807

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.