5 years ago

Highlights from this issue

The taming of the shrew

It may come as some surprise that the hedgehog is a distant relative of the shrew, and even more of a surprise that hedgehogs native to North America are now extinct and have never been present in Australia. However, hedgehog and its signalling pathways are increased in Idiopathic Pulmonary Fibrosis (IPF). In this issue of Thorax, Jia and colleagues describe how the chemokine CXCL14 is increased in mice in response to Hedgehog overexpression and is elevated in the plasma from patients with IPF (see page 780). In an effort to tame this shrew a hedgehog inhibitor has been developed and has been shown to inhibit CXCL14 in patients treated with cancer. Therefore, it is hoped CXCL14 can be used as a biomarker to demonstrate whether vismodegib can tame both the shrew and IPF.

The merry widows of windsor


Publisher URL: http://thorax.bmj.com/cgi/content/short/72/9/i

DOI: 10.1136/thoraxjnl-2017-210807

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