4 years ago

Short course treatment for MDR TB: jumping the gun?

Multidrug-resistant (MDR)-TB is threatening TB control worldwide. The conventional treatment lasts 20–24 months, is often toxic and half of the treated patients have poor outcomes. WHO has recently recommended a shorter regimen with treatment duration of 9–12 months, aiming for higher effectiveness, tolerability, adherence and completion rates.1 This shorter regimen is recommended for patients with pulmonary TB who have not been previously exposed to second-line drugs for more than 1 month and have no confirmed or suspected resistance to drugs in the regimen, except high-dose isoniazid. Recommendations were based on the promising results of large observational cohorts in Asia and Africa.

In Thorax, Yanina Balabanova and colleagues assessed the proportion of adult smear-positive pulmonary MDR-TB cases who might have been eligible for the shorter regimen. The patients were initially recruited in 2007 and 2009 and followed up till 2012 in four eastern European countries, who participated in the European Union-funded...

Publisher URL: http://thorax.bmj.com/cgi/content/short/72/9/773

DOI: 10.1136/thoraxjnl-2017-210163

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