3 years ago

Metal-Free Electrophilic Phosphination/Cyclization of Alkynes

Metal-Free Electrophilic Phosphination/Cyclization of Alkynes
Yuto Unoh, Masahiro Miura, Koji Hirano
A metal-free electrophilic phosphination reaction has been developed. Electrophilic phosphorus species generated in situ from secondary phosphine oxides and Tf2O smoothly couple with alkynes possessing pendant nucleophiles to afford the corresponding phosphinated cyclization products in good yield. Preliminary NMR studies show that phosphirenium species may be involved as intermediates of the cyclization reactions.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b02977

DOI: 10.1021/jacs.7b02977

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