Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Diversification of Quinazolinones by Pd-Catalyzed C(sp3)-Acetoxylation

Diversification of Quinazolinones by Pd-Catalyzed C(sp3)-Acetoxylation
Dnyaneshwar N. Garad, Santosh B. Mhaske
The quinazolinone ring has been exploited as a directing group for C(sp3)–H functionalization for the first time. The proximal C−γ(sp3)–H bonds have been oxidized by palladium-catalyzed acetoxylation reaction. Various functional groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives. The use of base was found to be crucial for the monoselective acetoxylations.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01934

DOI: 10.1021/acs.joc.7b01934

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.