5 years ago

Diversification of Quinazolinones by Pd-Catalyzed C(sp3)-Acetoxylation

Diversification of Quinazolinones by Pd-Catalyzed C(sp3)-Acetoxylation
Dnyaneshwar N. Garad, Santosh B. Mhaske
The quinazolinone ring has been exploited as a directing group for C(sp3)–H functionalization for the first time. The proximal C−γ(sp3)–H bonds have been oxidized by palladium-catalyzed acetoxylation reaction. Various functional groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives. The use of base was found to be crucial for the monoselective acetoxylations.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01934

DOI: 10.1021/acs.joc.7b01934

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