5 years ago

Pyridine-Directed Asymmetric Hydrogenation of 1,1-Diarylalkenes

Pyridine-Directed Asymmetric Hydrogenation of 1,1-Diarylalkenes
Hailong Yang, Xumu Zhang, Ping Yang, Hui Lv, Erfei Wang
Highly enantioselective pyridine-directed rhodium-catalyzed asymmetric hydrogenation of challenging 1,1-diarylalkenes is achieved by using [Rh(NBD)DuanPhos]BF4 as a precatalyst. Various types of 2-pyridine substituted 1,1-diarylalkenes could be hydrogenated with good to excellent enantioselectivities, which provide an efficient route to the synthesis of pharmaceutically and biologically active compounds containing a 2-pyridyl ethane unit.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02262

DOI: 10.1021/acs.orglett.7b02262

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