5 years ago

Luminescent and Magnetic α-Fe2O3@Y2O3:Eu3+ Bifunctional Hollow Microspheres for Drug Delivery

Luminescent and Magnetic α-Fe2O3@Y2O3:Eu3+ Bifunctional Hollow Microspheres for Drug Delivery
Liaoyuan Xia, Fangjia Zhu, Le Huang, Shaoheng Hu, Xiangling Li
Fluorescent and magnetic bifunctional nanomaterials have found several applications in life sciences, including biological labeling, magnetic resonance imaging, gene therapy, and nanodrug delivery. In this work, we develop a facile route that combines the assisted-template approach with a homogeneous co-precipitation method and a high-temperature calcination process, allowing the successful preparation of fluorescent–magnetic α-Fe2O3@Y2O3:Eu3+ bifunctional hollow microspheres (BHMs) with mesoporous shells and hollow-core structures. Scanning electron microscopy, transmission electron microscopy, emission spectroscopy, magnetic testing, and N2 adsorption techniques were employed to characterize the fluorescent–magnetic α-Fe2O3@Y2O3:Eu3+ BHMs. The results showed that the resulting BHMs exhibited uniformly spherical morphologies with mesoporous shells and hollow-core structures and were characterized by good dispersibility, photofluorescence, and magnetic responsiveness in solution. Ibuprofen loading and drug-release simulation experiments showed that the BHMs exhibited a high drug-loading capacity (126 mg/g) and a sustained drug-release profile, which would allow them to be employed as nanodrug carriers for the therapeutic treatment of malignant tumors.

Publisher URL: http://dx.doi.org/10.1021/acs.jpcc.7b05228

DOI: 10.1021/acs.jpcc.7b05228

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