Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells

Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells
Sally E. Plush, Karen D. M. MaGee, Chiara Caporale, Todd A. Gillam, Alexandra Sorvina, Stefano Stagni, Phillip J. Wright, Paolo Raiteri, Massimiliano Massi, Janna L. Morrison, Brian W. Skelton, Christie A. Bader, Douglas A. Brooks
Luminescent iridium tetrazolato complexes can be exploited for live cell imaging, and their cellular localization can be modulated by simple methylation of these neutral species to yield the corresponding cationic complexes. The neutral family of complexes displays a tendency to accumulate within the endoplasmic reticulum and, to a variable extent, lipid droplets. The analogous cationic complexes display a tendency to localize primarily in mitochondria. Interestingly, the neutral complexes highlight very low cytotoxicity when compared to their corresponding cationic species. More information can be found in the Full Paper S. E. Plush, D. A. Brooks, M. Massi et al. (DOI: 10.1002/chem.201701352).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201704087

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