Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes

Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes
Tao Ding, Hao Xu, Liyang Pan, Xiaomin Fang, Yuanqing Xu, Wenkai Zhang, Zhenxing Li
A simple and efficient method for the base-mediated synthesis of unsymmetrical 1,3,5-triazin-2-amines has been developed. The protocol uses readily available imidates, guanidines, and amides or aldehydes as the starting materials, cesium carbonate as the base, no catalyst or additive is required, and the three-component reaction provides diverse 1,3,5-triazin-2-amines in moderate to good yields with tolerance of wide functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01510

DOI: 10.1021/acs.joc.7b01510

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