Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences

Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences
Helma Wennemers, Matthew R. Aronoff, Stefanie Dobitz
Nature utilizes large biomolecules to fulfill tasks that require spatially well-defined arrangements at the molecular level such as electron transfer, ligand–receptor interactions, or catalysis. The creation of synthetic molecules that enable precise control over spacing and functionalization provides opportunities across diverse disciplines. Key requirements of functionalizable oligomeric scaffolds include the specific control of their molecular properties where the correct balance of flexibility and rigidity must be maintained in addition to the prerequisite of defined length. These molecules must ideally be equally applicable in aqueous and organic environments, they must be easy to synthesize in a controlled stepwise fashion, and they must be easily modified with a palette of chemical appendages having diverse functionalities.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00340

DOI: 10.1021/acs.accounts.7b00340

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