Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities

Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities
Yoshiki Morimoto, Haruka Nokubo, Takeshi Kodama, Tomoyuki Koyama, Kengo Yamauchi, Momochika Kumagai, Kunihiro Matsumura, Shinnosuke Ezaki, Keisuke Nishikawa, Seiho Kikuchi
A phenomenon of enantiodivergence was found in lepadiformine marine alkaloids isolated from a single species marine tunicate Clavelina moluccensis. The enantioselective total syntheses have been achieved by key mercury(II) triflate-catalyzed cycloisomerization reaction from a functionalized linear substrate to a 1-azaspiro[4.5]decane compound, and cytotoxic activities of synthesized lepadiformines and their synthetic intermediates were also evaluated. More information can be found in the Full Paper by Y. Morimoto et al. (DOI: 10.1002/chem.201701475).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702291

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