5 years ago

Near infrared spectroscopy: a tool for solid-state characterization

Near infrared spectroscopy: a tool for solid-state characterization
Physical characterization of solid drugs is of paramount importance because the biopharmaceutical properties and/or processing behavior can be altered. Early identification and monitoring of solid-state transformation is a crucial requirement for pharmaceutical product development. In combination with chemometrics, a nondestructive and noninvasive technique such as near infrared spectroscopy (NIR) is a powerful tool for solid-state characterization. The main focus of this review is the application of NIR for qualitative and quantitative analysis of solid forms of drugs and excipients. In addition, this review also sheds light on recent advances in NIR, such as NIR chemical imaging and NIR-based hyphenated techniques.

Publisher URL: www.sciencedirect.com/science

DOI: S1359644617300740

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