Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters
5 years ago

Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification- Part II

Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification- Part II
N-substituted azaindoles have been discovered as pan-PIM kinase inhibitors. Initial SAR, early ADME and PK/PD data of a series of compounds is described and led to the identification of promising pan-PIM inhibitors which validated our interest in the 7-azaindole scaffold and led us to pursue the identication of a clinical candidate

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17308715

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