4 years ago

Living donor liver transplantation for biliary atresia: An analysis of 2,085 cases in the registry of the Japanese Liver Transplantation Society

, Eiji Kobayashi, Yukihiro Inomata, Mureo Kasahara, Eiji Tanaka, Shinji Uemoto, Hiroyuki Furukawa, Akinari Fukuda, Seisuke Sakamoto, Shotaro Sakisaka, Hideki Ohdan, Norihiro Kokudo, Seiji Kawasaki, Hiroto Egawa, Mitsuo Shimada, Koji Umeshita
Biliary atresia (BA) is the most common indication for liver transplantation (LT) in pediatric population. This study analyzed the comprehensive factors that might influence the outcomes of patients with BA who undergo living donor LT by evaluating the largest cohort with the longest follow-up in the world. Between November 1989 and December 2015, 2,085 BA patients underwent LDLT in Japan. There were 763 male and 1,322 female recipients with a mean age of 5.9 years and body weight of 18.6 kg. The 1-, 5-, 10-, 15-and 20-year graft survival rates for the BA patients undergoing LDLT were 90.5%, 90.4%, 84.6%, 82.0% and 79.9%, respectively. The donor body mass index, ABO incompatibility, graft type, recipient age, center experience and transplant era were found to be significant predictors of the overall graft survival. Adolescent age (12 to <18 years) was associated with a significantly worse long-term graft survival rate than younger or older ages. We conclude that LDLT for BA is a safe and effective treatment modality that does not compromise living donors. The optimum timing for LT is crucial for a successful outcome, and early referral to transplantation center can improve the short-term outcomes of LT for BA. Further investigation of the major cause of death in liver transplanted recipients with BA in the long-term is essential, especially among adolescents. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14489

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