Chemical Biology and Drug Design
Chemical Biology and Drug Design
5 years ago

Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation

Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation
Vipan Kumar, Philip J. Rosenthal, Anu Rani, Jiri Gut, Amandeep Singh
A series of piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates were prepared with a view to evaluate their activities against Plasmodium falciparum. The synthesized conjugates had in vitro IC50 values from 0.41 to 2.38 μm against chloroquine-resistant and mefloquine-sensitive W2 strain of P. falciparum. The submicromolar activities of most of the synthesized conjugates suggest that such molecular frameworks can act as therapeutic templates for the design and synthesis of new antimalarials. Synthesis of piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates and their evaluation against chloroquine-resistant and mefloquine-sensitive W2 strain of Plasmodium falciparum.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.12982

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