3 years ago

Development and Characterization of electrosprayed Nanoparticles for encapsulation of Curcumin

Seyed Shahrooz Zargarian, Zahra Esmaili, Hamid Akbari Javar, Ehsan Seyedjafari, Samaneh Bayrami, Farid Abedin Dorkoosh, Vahid Haddadi-Asl
Curcumin has been proven to be an effective herbal derived anti-inflammatory and antioxidant biocompatible agent. In this research PLGA (as a biocompatible and GRAS polymer) nanoparticles containing Curcumin were electrospryed from different polymeric solutions with different concentrations for the first time. Morphology of these nanoparticles in the absence/presence of Curcumin was evaluated by SEM, TEM and XPS analyses. Perfectly shaped nanoparticles with an average size of 300 and 320 nanometers were observed for neat and Curcumin loaded PLGA, respectively. Curcumin-loaded electrosprayed nanoparticles showed a normal moderate initial burst and then a prolonged release period. Weibull, Peppas and modified Korsmeyer-Peppas models were applied to study the kinetic and mechanism of curcmin release from PLGA nanoparticles. Results showed high specific surface area and spherical geometry of the nanoparticles. Effectiveness of the electrospray method as a promising technique for preparing Curcumin-loaded nanoparticles was confirmed in this study. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbm.a.36233

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