Journal of Clinical Microbiology
Journal of Clinical Microbiology
5 years ago

Towards a universal molecular microbiological test.

Jennison AV, Allcock RJN, Warrilow D
The standard paradigm for microbiological testing is dependent on presentation of a patient to a clinician. Tests are then requested based on differential diagnoses using the patient's symptoms as a guide. The era of high-throughput genomic methods has the potential to replace this model for the first time with what could be referred to as "hypothesis-free testing." This approach utilizes one of a variety of methodologies to obtain sequence from potentially any nucleic acid in a clinical sample, without prior knowledge of its content. We discuss the advantages of such an approach and the challenges in making this a reality.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28835478

DOI: PubMed:28835478

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