4 years ago

Serum HBV DNA, RNA and HBsAg: which correlated better to intrahepatic covalently closed circular DNA before and after nucleos(t)ide analogue treatment?

Gao Y, Zhang Z, Liu X, Li T, Su M, Shang Q, Zhao P, Meng Q, Zhuang H, Li Y
The study was to investigate whether serum HBV RNA is a strong surrogate marker for intrahepatic HBV covalently closed circular DNA (cccDNA) when compared with serum HBV DNA, hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in HBeAg-positive chronic hepatitis B (CHB) patients. Serum HBV RNA, HBV DNA, HBsAg, HBeAg and intrahepatic cccDNA were quantitatively detected at baseline (n=82) and 96 weeks (n=62) after nucleos(t)ide analogues (NUC) treatment in HBeAg-positive CHB patients. Then the correlations between serum HBV RNA, HBV DNA, HBsAg, HBeAg and intrahepatic cccDNA were statistically analyzed. The results showed that pre-treatment intrahepatic cccDNA was correlated better with serum HBV DNA (r=0.36, P<0.01) than with serum HBV RNA (r=0.25, P=0.02), whereas no correlations were found between pre-treatment intrahepatic cccDNA and HBsAg (r=0.15, P=0.17), HBeAg (r=0.07, P=0.56). At 96 weeks after NUC treatment, intrahepatic cccDNA was correlated well with HBsAg (r=0.39, P<0.01), but not with serum HBV RNA, HBV DNA and HBeAg (all P>0.05). Besides, the declined value in intrahepatic cccDNA from baseline to week 96 was correlated better with the reduction in serum HBsAg than with the decreases in other markers (r=0.38, P<0.01, for HBsAg decline; r=0.35, P=0.01, for HBV DNA decline; r=0.28, P<0.05, for HBV RNA decline; r=0.18, P=0.19, for HBeAg decline). In conclusion, baseline serum HBV RNA or its decline after 96-week NUC therapy was correlated with the corresponding intrahepatic cccDNA, while it was inferior to serum HBV DNA at baseline and HBsAg (or its decline) at 96 weeks after treatment, respectively.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28747369

DOI: PubMed:28747369

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