3 years ago

Modulation of CD4(+) and CD8(+) T cell function and cytokine responses in Strongyloides stercoralis infection by IL-27 and IL-37.

Babu S, Dolla C, Nutman TB, Kumaran P, Munisankar S, Anuradha R, Bhootra Y
Strongyloides stercoralis (Ss) infection is associated with diminished antigen - specific Th1- and Th17-associated responses and enhanced Th2-associated responses. IL-27 and IL-37 are 2 known anti-inflammatory cytokines that are highly expressed in Ss infection. We, therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4+ and CD8+ T cell responses in Ss infection. To this end, we examined the frequency of Th1/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17 and Th22/Tc22 cells in 15 Ss- infected individuals and 10 uninfected individuals, stimulated with parasite antigen following IL-27 or IL-37 neutralization. We also examined the production of prototypical Type 1, Type 2, Type 9, Type 17 and Type 22 cytokines in the whole blood supernatants. Our data reveal that IL-27 or IL-37 neutralization resulted in significantly enhanced frequencies of Th1/Tc1, Th2/Tc2, Th17/Tc17, Th9 and Th22 cells with parasite antigen stimulation. There was no induction of any T cell response in uninfected individuals following parasite antigen stimulation and IL-27 or IL-37 neutralization. Moreover, we also observed increased production of IFNγ, IL-5, IL-9, IL-17 and IL-22 and decreased production of IL-10 following IL-27 and IL-37 neutralization and parasite antigen stimulation in whole blood cultures. Thus, we demonstrate that IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in Ss infections and suggests the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28874444

DOI: PubMed:28874444

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.