5 years ago

Caspase-11 plays a protective role in pulmonary A. baumannii infection.

Wang W, Ma T, Shao Y, Song M, Xin N, Li S, Zhao C
Activation of caspase-11 by some gram negative bacteria triggers caspase-1/IL-1β pathway independent of canonical inflammasomes. Acinetobacter baumannii (A. baumannii) are gram negative, conditional pathogenic bacteria, which can lead to severe pulmonary infection in hospitalized patients. A. baumannii were revealed to activate canonical and noncanonical inflammasome pathway in bone marrow-derived macrophages (BMDMs). Pulmonary infection of caspase-11-/- mice with A. baumannii showed that caspase-11 deficiency impaired A. baumannii clearance, exacerbated pulmonary pathological changes, and enhanced the susceptibility to A. baumannii These data indicate that caspase-11-mediated innate immune response plays a crucial role in defending against A. baumannii.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28760936

DOI: PubMed:28760936

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