5 years ago

Neutrophils are Central to Antibody-Mediated Protection against Genital Chlamydia.

Morrison SG, Naglak EK, Morrison RP
Determining the effector populations involved in humoral protection against genital chlamydia infection is crucial to development of an effective chlamydial vaccine. Antibody has been implicated in protection studies in multiple animal models, and we previously showed that the passive transfer of immune serum alone does not confer immunity in the mouse. Using the Chlamydia muridarum model of genital infection, we demonstrate a protective role for both Chlamydia-specific immunoglobulin (Ig) G and polymorphonuclear neutrophils, and show the importance of an antibody/effector cell interaction in mediating humoral immunity. While neutrophils were found to contribute significantly to antibody-mediated protection in vivo, Natural Killer (NK) cells were dispensable for protective immunity. Furthermore, gamma interferon (IFN-γ)-stimulated primary peritoneal neutrophils (PPNs) killed chlamydiae in vitro in an antibody-dependent manner. The results from this study support the view that an IFN-γ-activated effector cell population cooperates with antibody to protect against genital chlamydia, and establishes neutrophils as a key effector cell in this response.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28739831

DOI: PubMed:28739831

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