Current Medicinal Chemistry
Current Medicinal Chemistry
5 years ago

A therapeutic connection between dietary phytochemicals and ATP synthase.

Azim S, Hassan SS, Ahmad Z
For centuries, phytochemicals have been used to prevent and cure multiple health ailments. Phytochemicals have been reported to have antioxidant, antidiabetic, antitussive, antiparasitic, anticancer, and antimicrobial properties. Generally, the therapeutic use of phytochemicals is based on tradition or word of mouth with few evidence-based studies. Moreover, molecular level interactions or molecular targets for majority of phytochemicals are unknown. In recent years, antibiotic resistance by microbes has become a major healthcare concern. As such, the use of phytochemicals with antimicrobial properties has become pertinent. Natural compounds from plants, vegetables, herbs, and spices with strong antimicrobial properties present an excellent opportunity for preventing and combating antibiotic resistant microbial infections through selective inhibition of microbial ATP synthase. In this review the therapeutic connection between dietary phytochemicals and ATP synthase is summarized based on the inhibition of ATP synthase by dietary phytochemicals.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28831918

DOI: PubMed:28831918

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